Single gene deletions of orexin, leptin, neuropeptide Y, and ghrelin do not appreciably alter food anticipatory activity in mice.

Beginning on day 7, WT CR had a significant increase in fraction of high activity preceding feeding which remained highly significant through day 28.

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The lack of a significant increase in FAA in ghrelin KO mice on day 7 could be interpreted as delayed onset of the acquisition of FAA but in contrast with orexin KO mice on CR diets there is an obvious trend toward increasing high activity behaviors in NPY KO CR mice at this time point.

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The lack of significant increase in FAA in NPY KO mice until day 14 could be interpreted as a delayed onset of FAA in NPY KO mice since FAA is significantly increased in NPY WT mice on CR from day 7 though it is clear that there is a strong trend toward increased activity in the three hrs preceding feeding at day 7 in the NPY KO mice on CR.

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