Moreover, and consistently with the tumour re-growth, following cessation of either AZD8055 or GDC-0941 for 5 weeks, the morphology of the tumours from these mice also showed a trend towards progression to diffuse large B-cell lymphoma ( Figure 6C , panels g, f, k and l).
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Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice.
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