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Global gene expression profiling of endothelium exposed to heme reveals an organ-specific induction of cytoprotective enzymes in sickle cell disease.

PLoS One · 2011 · PMC3069101 · PMID 21483798

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The difference in HO-1 mRNA level in SS, AS and AA lungs did not reach statistical significance, while no differences were found for this transcript in the brains of SS, AS and AA mice ( Figure 5A ).

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