A study to investigate the role of p27 and cyclin E immunoexpression as a prognostic factor in early breast carcinoma.

The association with oestrogen receptor status showed near significance (Table 3 ).

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The authors also report a tendency towards better survival for tumours with more than 25% of p27 positive tumour cells, but this result did not reach statistical significance.

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When specific types of metastases were analysed, high cyclin E predicted the risk of distant metastases with borderline significance on multivariate analysis whereas both overexpressed cyclin E and the younger age of patients were independent risk factors for visceral relapse.

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