Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses.

Therefore, we conclude that all tested compounds are effective in elimination of lysosomal storage from MPS cells, despite the fact that only some of these flavonoids (daidzein and kaempferol) caused statistically significant inhibition of GAG synthesis, while the levels of the inhibition by apigenin and naringenin did not reach statistical significance (compare Table 2 and Fig. 2 ).

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