Atrioventricular and interventricular delay optimization in cardiac resynchronization therapy: physiological principles and overview of available methods.

However, the larger, randomized DECREASE-HF trial showed a trend toward greater reduction in left ventricular systolic diameter for the group with simultaneous biventricular pacing compared to sequential biventricular pacing [ 44 ], and the single-blinded, randomized RHYTHM-II trial did not find a benefit on functional endpoints of VV optimization compared to simultaneous biventricular pacing [ 45 ].

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