TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice.

There was also a suggestion that the increase in smooth muscle cells in the atherosclerotic plaques from TRAIL −/− ApoE −/− animals at 12 weeks coincided with a reduction in apoptosis as analysed by TUNEL but, again, this did not reach statistical significance ( Supplementary figure ).

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This effect was only clearly seen at this timepoint and although there was a positive trend for an increase in VSMC lesion content at 12 weeks, this was not significant in either chow or Western diet fed animals.

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