Metabolomics reveals target and off-target toxicities of a model organophosphate pesticide to roach (Rutilus rutilus): implications for biomonitoring.

Steroid Metabolism Cortisone showed a significant 4.0-fold depletion, from SC to 200 μg/L exposure, in response to fenitrothion ( p = 0.004, post hoc: 200 μg/L group significantly different from WC, SC, and 2 μg/L exposure), and 11-hydroxyandrostenedione showed a near-significant 2.9-fold increase from SC to 200 μg/L exposure ( p = 0.057, Figure 2 A,B).

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In the DIMS liver data set the identities of creatine, phosphocreatine, and tyrosine were confirmed by observation of highly significant correlations between the NMR and DIMS peak intensities (Table S10, Supporting Information ), which also illustrated the high consistency between the analytical methods for these metabolites (further highlighted in Table S13 in Supporting Information ).

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