Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy.

Lipids Health Dis · 2011 · PMC3078893 · PMID 21450082

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a significant trendno p-value reported

demonstrates a significant trend for early coronary revascularization surgery for patients with higher number of copies of the ε4 allele, compared with ε3 and ε2 carriers[ 12 ].

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