Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.

When the HF patients were treated with continuous-flow LV assist device (LVAD) for 8±1.7 months, improvement in hemodynamic parameters (LV end diastolic volume decreased from 294.9 mL to 237.8 mL, LV diastolic diameter from 7.6 cm to 6.8 cm, and LV end systolic volume from 244.8 mL to 183.4 mL, reflected in an increase in LVEF from 18.2 to 29.6%, p<0.05 for all) was accompanied by a marked decrease in mRNA levels of CXCR5 as well as biglycan and fibromodulin, although the decrease in fibromodulin did not reach statistical significance ( Fig. 8 ).

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