hHGF overexpression in myoblast sheets enhances their angiogenic potential in rat chronic heart failure.

In the border area of the failing hearts, L6-HGF sheets again induced a highly significant increase of 109% and 59% in SMA-positive (2.66±0.29) and vWF-positive (0.78±0.05) tissue respectively (control SMA 1.27±0.29, vWF 0.49±0.07, p<0.001 for both; L6-WT SMA 1.69±0.15, p<0.01; vWF 0.64±0.05, p<0.05).

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In L6-HGF group, however, the effect was less evident (0.81±0.03) and failed to reach statistical significance ( Figure 4A ).

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