Variation in the FFAR1 gene modifies BMI, body composition and beta-cell function in overweight subjects: an exploratory analysis.

Effect of FFAR1 polymorphisms on measures of insulin sensitivity There was a nominally significant (unadjusted) association of the G allele of rs2301151 with a ∼73% higher disposition index (DI) and a trend (P = 0.06) towards a ∼52% higher endogenous (1st phase/acute) insulin release (AIRg) when assessed as the recessive model only, accounting for age, gender and BMI ( Table S2 ).

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