Barely Significant
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Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk.

PLoS One · 2011 · PMC3084737 · PMID 21559498

1
hedged sentence
0.0000
closest p · 0.0× alpha
0.0000
boldest claim

The sentences

a strong trendP = 3.01×10 −21actually significant
Furthermore, there was however a strong trend in CPD across age groups; cases in the uppermost quantile having a cigarette consumption of 3.2 CPD less than those in the lowest age quantile ( P = 3.01×10 −21 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.