Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production.

PLoS One · 2011 · PMC3085474 · PMID 21559358

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did not reach statistical significanceno p-value reported

23%); however, the magnitude of this difference did not reach statistical significance for the number of mice analyzed.

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may be significantno p-value reported

Combination therapy generated higher fractions of both KLRG1+ CD8+ and CD4+ effector T-cells in the context of FVAX versus GVAX which may be significant in explaining the lack of cooperativity observed with GVAX ( Figure S7 ).

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