The pooled analyses of patients achieving Hb A1C ≤ 7% favoured the addition of insulin; however, this finding did not reach statistical significance (RR 1.10; 95% CI 0.80–1.52).
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Insulin versus an oral antidiabetic agent as add-on therapy in type 2 diabetes after failure of an oral antidiabetic regimen: a meta-analysis.
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