Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.

Analyses using median HDL included adjustments for smoking, age, age 2 , BMI, BMI 2 , and gender, as all of these factors showed highly significant associations with median HDL.

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For the gene-gene interaction replication set using Vanderbilt BioVU samples in a combination of both European-Americans and African-Americans, we identified and excluded 5 ethnic outliers and adjusted analyses for two marginally significant principle components using Eigensoft [49] .

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We found 11 interactions that were nominally significant in our discovery cohort (the Marshfield PMRP biobank).

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