Barely Significant
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Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response.

PLoS One · 2011 · PMC3093392 · PMID 21589866

Europe PMCDOI
1
hedged sentence
0.1360
closest p · 2.7× alpha
0.1360
boldest claim

The sentences

did not reach statistical significancep = 0.136not close (p > 0.1)
Although it did not reach statistical significance, Responder patients presented higher methadone plasma concentrations of both, ( R )- (responders 311 ng/ml [SD = 259] vs. nonresponders 238 ng/ml [SD = 131], p = 0.136) and ( S )-methadone (responders 276 ng/ml [SD = 268] vs. nonresponders 205 ng/ml [SD = 121], p = 0.370) and, also, ( R,S )-methadone (responders 587 ng/ml [SD = 501] vs. nonresponders 443 ng/ml [SD = 246], p = 0.121).

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