Acute decreases in proteasome pathway activity after inhalation of fresh diesel exhaust or secondary organic aerosol.

Analysis of the two pollutant aerosols separately showed SOA exposure was associated with a similar decline [effect estimate = −1928.5 (−11.6%); 95% CI, −3665.1 to −191.9; p = 0.03]; DE also decreased this activity, but did not reach statistical significance [effect estimate = −1070.9 (−6.4%); 95% CI, −2635.6 to 493.7; p = 0.17].

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Using mixed linear models, borderline significant decreases in RBC proteasome activity were observed after exposure to DE or SOA, when compared with exposure to CA [effect estimate = −204.7 (−7.9%); 95% CI, −425.9 to 16.5; p- value = 0.06] ( Table 4 ).

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