17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2.

Breast Cancer Res · 2010 · PMC3096977 · PMID 20946630

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0.1500

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did not reach statistical significanceP = 0.15not close (p > 0.1)

Finally, intracellular choline levels were elevated to 194% ± 81% of control with treatment, from 1.1 ± 0.5 fmol/cell in control cells to 2.1 ± 0.8 fmol/cell in 17-AAG-treated cells, although this change did not reach statistical significance ( n = 3, P = 0.15).

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