A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer.

Despite these measures, only the HRneg/Tneg index demonstrated significant Kaplan-Meier curve separation, whereas the previously reported IR signature and two other immune-related signatures approached significance in our pooled validation cohort only.

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Only a small subset of the dataset tumors was clinically annotated for degree of lymphocytic infiltration [ 6 , 29 ], and an initial analysis of these few Tneg cases suggested a possible trend between the HRneg/Tneg score and the degree of lymphocytic infiltration (data not shown).

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