Association of HbA1c values with mortality and cardiovascular events in diabetic dialysis patients. The INVOR study and review of the literature.

A non-linear P-spline showed that the association did not follow a fully linear pattern with a highly significant non-linear component (p = 0.001) with an increased risk of all-cause mortality for HbA 1c values up to 6–7%.

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A non-linear P-spline on the fully adjusted model showed a trend for higher HbA 1c values towards an increasing risk of CVD events, but neither the linear nor the non-linear component of the P-spline were significant ( Figure 2 and Table 4 ).

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Figure 2 showed a decreasing trend up to HbA 1c values of ∼7%, which flattens afterwards.

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Furthermore, a borderline significant association could be found between HbA 1c measurements and CVD events.

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