A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria.

After adjustment for multiple testing, the association of c.−436C>A in the logistic regression analysis remained significant for the additive model of inheritance (p empirical = 0.02) and reached borderline significance for the dominant model (p empirical = 0.05) ( Table 1 ).

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As the significant findings obtained with c.−436C>A were limited to the assumption of an additive inheritance mode, the association of c.334+46C>T being of borderline significance was not pursued further.

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c.334+46C>T, an intronic FAS variant which was associated with marginal significance, was not linked to −436C>A and followed a discordant model of inheritance.

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