Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglect.

Front Psychiatry · 2011 · PMC3098717 · PMID 21629843

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approached significanceno p-value reported

We also observed downregulation of two genes associated with oligodendrocytes, including Enpp2 (see Tables S2 and S3 ) and Mbp (see Table S3 in Supplementary Material), and a third gene Nkx6-2 approached significance for the B6 mice only ( Q = 0.016; data not shown).

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highly significantno p-value reported

We report highly significant effects of MSEW on the expression of mRNAs and proteins involved in myelination and protein translation, in addition to other categories relevant to neurodevelopment.

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