MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection.

Although there was a tendency towards elevated bacterial titers in the ipsilateral and contralateral hemispheres of TLR4 mutant mice at days 3 and 7 post-infection (Figure 6B and 6C , respectively), these differences did not reach statistical significance in a total of five independent experiments (data not shown).

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