Copy number variation analysis in single-suture craniosynostosis: multiple rare variants including RUNX2 duplication in two cousins with metopic craniosynostosis.

Am J Med Genet A · 2010 · PMC3104131 · PMID 20683987

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)

Although it is possible that gene disruption, in addition to or distinct from gene dosage, may influence phenotypic outcome in craniosynostosis our data did not reach statistical significance for this hypothesis ( P = 0.06).

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