Rationale and study design of PROVHILO - a worldwide multicenter randomized controlled trial on protective ventilation during general anesthesia for open abdominal surgery.

If the intervention has a strong trend for improving post-operative pulmonary complications (as defined above) with a p -value < 0.0005 is found at 300 patients or <0.014 at 600 patients, termination of the study is considered.

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