Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and COX-2 inhibitors.

Drug Healthc Patient Saf · 2009 · PMC3108684 · PMID 21701610

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a nonsignificant trendno p-value reported

78 , 87 Etoricoxib demonstrated a nonsignificant trend in reducing the risk of POBs (RR 0.82; 95% CI 0.44 to 1.51, random effects), but it significantly reduced the RR of PUBs by 46% (RR 0.64; 95% CI 0.42 to 0.96).

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did not reach statistical significanceno p-value reported

Among 34,000 patients in the tNSAID arms of these studies, those taking ASA had a 1.65 greater relative risk of POBs than those not taking ASA, although this result did not reach statistical significance (95% CI 0.76 to 3.57).

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