69 Siu and colleagues published a small controlled trial that showed a trend toward preservation of GFR using allopurinol in hyperuricemic patients with mild to moderate CKD. 56 A recently presented abstract found that long-term febuxostat improved or preserved GFR in gouty patients. 70 There have been several critical reviews of the evidence linking hyperuricemia in a causative role with cardiovascular disease, with the conclusion being that the association seems reasonably strong, but is not yet definitive. 71 , 72 Does hyperuricemia directly cause hypertension?
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