A novel study and meta-analysis of the genetic variation of the serotonin transporter promoter in the italian population do not support a large effect on Alzheimer's disease risk.

Int J Alzheimers Dis · 2011 · PMC3109656 · PMID 21660253

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a positive trendno p-value reported

However, this observation should suffer from reduced sample size in the groups analyzed, even though both in AD APOE- ε 4 carriers (+) and AD noncarriers (−) the 5-HTTLPR S-allele frequency had a positive trend in comparison to controls.

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nominally significantno p-value reported

Overall, we acknowledge that the result of our novel association study is most likely inflated by type-I error, while the meta-analysis results do not provide nominally significant evidence for association.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.