Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.

In our UK-based studies (totalling >17,000 individuals, with fasting glucose measures in ~12,300 individuals), we identified a borderline significant association between rs553668 and fasting glucose measures, with each minor allele being associated with a mean increase of 0.030 mmol/l (95% CI 0.006–0.054; p = 0.016).

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For type 2 diabetes risk, the haplotypes with the minor allele of rs553668 and major allele of rs10885122 (rs553668A/rs10885122G) showed a trend to association with type 2 diabetes risk (OR 1.16, p = 0.03, FDR p = 0.2).

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