GABA concentrations were significantly higher in LRRK2+/− neuronal cultures compared to wildtype controls (82.0±3.3 versus 58.3±2.8 nmol/g protein, LRRK2-deficient versus wildtype cultures, mean ± SD, n = 3 each), and glutamate concentrations showed a trend towards an increase (9.5±0.8 versus 8.5±0.1 μmol/g protein).
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Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells.
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