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High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children.

Malar J · 2011 · PMC3112455 · PMID 21569596

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What are the implications for IPTi-SP as a possible tool for malaria control in the Gabonese setting? The original IPTi trial in Gabon [ 21 ] yielded reductions in malaria episodes and anemia in the same order of magnitude as others [ 14 ], yet did not reach statistical significance due to a variety of reasons, including a pronounced Healthy Cohort Effect.

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