Eight of the nine -7/7q- t-AML/MDS cases occurred among patients with high-hyperdiploidy (n=4), t(12;21)(p13;q22) (n=1), or a normal/missing (n=4) karyotype at diagnosis of ALL, which indicates a biological propensity for non-disjunction, although the results did not reach statistical significance.
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Epidemiology of therapy-related myeloid neoplasms after treatment for pediatric acute lymphoblastic leukemia in the nordic countries.
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