Pre-injection of glyburide together with the K ATP activators reversed the anti-thermal nociceptive effects of the K ATP channel activators, although the effects of glyburide on diazoxide did not reach statistical significance (Figure 1B , Gly + Pin, 26 ± 1.7 s, n = 12; Gly + Dia, 31 ± 4.1 s, n = 10).
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Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.
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