Interferon signaling patterns in peripheral blood lymphocytes may predict clinical outcome after high-dose interferon therapy in melanoma patients.

CD4 T cells were on the cusp of significance (adjusted p-value, 0.052) and B cells showed no significant differences in STAT1 activation (adjusted p-value, 0.30) (Figure 1B ).

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IFN signaling patterns and clinical outcome It was observed that disease-free and overall survival was longer amongst patients with a clinical response at day 29 compared with non-responders, although the results did not reach statistical significance [ 12 ].

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