While the phospho-SMAD-1/5/8 staining level was low in the calcified ventricularis, it did not reach statistical significance in comparison to the calcified fibrosa ( Fig. 2G ).
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Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves--association with low BMP antagonists and SMAD6.
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