If you don't take it - it can't work: the consequences of not being treated or nonadherence to osteoporosis therapy.

The risk of nonvertebral fractures was 32% lower in patients treated with HRT, compared with patients in the placebo group, but did not reach statistical significance. 42 Data from a study of postmenopausal women who were randomized to receive treatment with raloxifene 60 mg or estrogen for 5 years showed that despite significant increases in lumbar spine BMD versus baseline ( P = 0.024 and P = 0.045, respectively), within 1 year of discontinuation of treatment lumbar spine BMD was significantly lower compared with the end-of-treatment values ( P = 0.001 and P = 0.012, respectively) ( Figure 1A ).

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