Lung metastatic ratio (the percentage of mice with metastasis out of the total number of mice with tumors) was lower in JAM-A−/− than in JAM-A+/+ mice although the difference did not reach statistical significance (51.2% versus 30.0% Fisher's test p = 0.091) ( Fig. 1B right panel).
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Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression.
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