Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell anemia patients, a basis for optimizing the dosing regimen.

Orphanet J Rare Dis · 2011 · PMC3118100 · PMID 21619673

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nearly significantno p-value reported

The OFVs of PK models with and without weight-scaling of V c and CL (as shown in methods section) were nearly significant, but this covariate was kept in the model for the sake of coherence with clinical practice and possible application of the model to children (where the effect of weight would be much more perceptible).

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