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Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis.

PLoS One · 2011 · PMC3120868 · PMID 21731723

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Interestingly, this difference did not reach statistical significance without LPS stimulation, suggesting that endotoxemia, as often observed in advanced liver diseases [41] , supports monocytic IL-8 secretion.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.