Although Klotho overexpression significantly reduced IL-8 in both culture media and cell lysates, MCP-1 production was significantly reduced only in culture media and did not reach statistical significance in cell lysates ( P = 0.08).
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Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation.
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0.0800