Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.

Although diacylglycerol levels trended higher in cocultured myotubes, differences between groups did not reach statistical significance ( Fig. 8 D , Supplementary Fig. 3 ), and concentrations of total ceramides ( Fig. 8 E ) and several subspecies ( Supplementary Fig. 3 ) were 29% lower after coculture ( P < 0.05).

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