Although the association between membrane BCRP/ABCG2 expression and the best response to gefitinib did not reach statistical significance, the group with negative membrane BCRP/ABCG2 expression showed a higher percentage of stable disease and partial response ( Table S2 ).
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Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells.
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