The clinical efficacy of L-DOPA and STN-DBS share a common marker: reduced GABA content in the motor thalamus.

However, examination of the individual patients' data showed a trend for no change in subjects presenting with low cGMP basal values (<1.5 fmol close to the detection limit), but a clear decrease (approximately 50%) after LD administration in subjects presenting with higher basal values (>3.0 fmol, patient-2 and 6; highlighted in Table 2 ).

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