TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation.

Naive TRPV3/TRPV4 double knockout mice again exhibited a small apparent increase in baseline response latency, compared with controls, although in this experiment that difference did not quite reach statistical significance (p = 0.051, n = 30-32, unpaired t-test).

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knockout: overall p < 0.01 in both comparisons, n = 10-12, two-way ANOVA with Bonferroni correction for repeated measures), although these differences did not reach statistical significance at any single time point (Figure 2C ).

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