Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.

J Biol Chem · 2011 · PMC3129207 · PMID 21606494

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantp < 0.001actually significant

This increased nestin immunoreactivity within APP clones was highly significant and represented a more than 40-fold induction (ANOVA, p < 0.001).

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failed to reach significancep = 0.06so close (0.05 < p ≤ 0.1)

3, J and L ) in APP-hESC clones, although these differences failed to reach significance (ANOVA, p = 0.06, p = 0.12, respectively).

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a strong trendno p-value reported

Interestingly, we found a strong trend toward reduced expression of both PS1 ( supplemental Fig. 3, I and K ) and nicastrin ( supplemental Fig. 3, J and L ) in APP-hESC clones, although these differences failed to reach significance (ANOVA, p = 0.06, p = 0.12, respectively).

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