Barely Significant
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The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men.

PLoS One · 2011 · PMC3131390 · PMID 21760950

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Two of these SNPs (rs1038304 and rs1999805) were also associated with lower BMD a at the lumbar spine with the other three SNPs showing a trend towards an association with lower BMD a at the lumbar spine that did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.