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A novel underuse model shows that inactivity but not ovariectomy determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats.

J Bone Miner Metab · 2011 · PMC3132588 · PMID 21127921

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The profiles of mineral parameters such as carbonate/phosphate ratio and crystallinity were similar for all five groups, and the Sham-Inactive mineral-to-matrix ratio showed a trend of generally higher ratio regardless of mineral or matrix species (Supplemental Fig.

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