Activation of cAMP/PKA and Ca 2+ signaling pathways with the PFI treatment also increased gene expression of two transcription factors involved in the stimulation of mitochondrial biogenesis, PGC-1α and PPARδ by 3- and 2-fold, respectively ( Table 2 ); however, these changes failed to reach statistical significance due to large variation.
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Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubes.
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