NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation.

In contrast, inhibition of RhoA using Y-27632, a cell-permeable inhibitor of the RhoA effector p160ROCK ( Figure 5D, E ), had a more limited effect, which did not reach statistical significance if both NEDD9 and BCAR1 were overexpressed.

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